Lethargy and increased respiratory rate are not specific symptoms as they are shared with many conditions; however I’m concerned that they are a common sign that an animal is in pain, but without examining Marilyn I cannot say whether she is in pain or there is another cause for the symptoms. You should visit your Veterinarian for an examination to be on the safe side especially if this has been going on for a day or more. Regards Dr Callum Turner DVM
Thank you for your email, I'm sorry that Cracker is having these problems. Without examining him, it is hard for me to advise you on whether he is suffering, and that is probably a question to ask the most recent veterinarian that you took him to. If he has a fungal or bacterial infection, he should be improving on those medications. If he has cancer, he may not improve, and it is important to assess his quality of life. If he starts breathing with his mouth open or stretching his neck to breathe, that is serious respiratory distress and is an emergency. IF he is eating and drinking and generally happy, he may be breathing heavier but not suffering. It would be best to have a recheck with the most recent veterinarian, as it has been a week on medications, and see if they feel he is improving - they may want to take x-rays and compare them with the previous x-rays to look for signs of improvement. They will be able to give you a better idea as to whether he may be suffering, or if he seems comfortable. I hope that all goes well with him.
My cat has began to be really affectionate. than started meow more and more often, noticed blood and i called vets, they said i can wait till next day for appointment as it doesn't seem to be serious. Right now she is started rapidly breathe and walks back and forth from my room to next room and getting comfy in the sheets. i know it could be signs of pregnancy, and her nipples are slightly swollen. but i only just noticed today and all been developing within the past 5 hours.
Cat sleeping all day which isn't like him at all. Once in awhile has asthma type cough gag hairball, once in awhile has tounge out and short shallow breaths. Lays long with body and neck stretched once in awhile. now he's been curled up in ball n won't move really except to lay down again or stretch. He's recently caught a mouse and bird. And month ago was sprayed in face area by a skunk. And just yesterday I noticed his back class are all split n frayed worn down.
Calico: Separate solid blocks of color, which must include red (orange), black, and white. They also may have blocks of tabby pattern, which produces an extremely colorful and beautiful cat. Dilute calicos, have the same separate blocks of color, only the colors are "diluted," i.e. "faded" shades of the original, which gives them an ethereal appearance. A dilute calico will have pale orange or buff for the red, and gray (or "blue") for the black.

Rapid breathing (tachypnea) is a respiratory disorder characterised by abnormal breathing that is rapid and shallow.  It is caused by a reduced level of oxygen, mechanical disorders (where the lungs aren’t able to expand as they should, usually due to a build-up of fluid in or around the lungs), and physiological disorders in which the cat’s respiratory centre in the brain is over stimulated.

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